Murine Mast Cells Secrete and Respond to Interleukin-33
نویسندگان
چکیده
منابع مشابه
Mast Cells Respond to Cell Injury through the Recognition of IL-33
Mast cells have been attributed several functions in both health and disease. Mast cell activation and release of inflammatory mediators are associated with the pathogenesis of several diseases, in particular that of allergic diseases. While the notion of mast cells as important, protective sentinel cells is old, this feature of the cell is not well recognized outside the mast cell field. The m...
متن کاملInterleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist’s Perspective
Interleukin (IL) 33, a member of the IL-1 superfamily, is an "alarmin" protein and is secreted in its active form from damaged cells undergoing necrotic cell death. Mast cells are one of the main effector cell types in allergic disorders. They secrete a variety of mediators, including T helper 2 cytokines. As mast cells have high-affinity IgE receptors (FcεRI) on their surface, they can capture...
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Interleukin 2 (IL-2) is a T cell-derived lymphokine that serves as a cofactor for the in vitro response of T lymphocytes to antigen and plays an important role in regulating the growth and/or differentiation of these cells (1, 2). It has been postulated (2, 3) that IL-2 is produced by a discrete regulatory T cell subset, with its effects being exerted on a second, functionally distinct subpopul...
متن کاملInterleukin-33 Primes Mast Cells for Activation by IgG Immune Complexes
Mast cells (MCs) are heterogeneous cells whose phenotype is modulated by signals received from the local microenvironment. Recent studies have identified the mesenchymal-derived cytokine IL-33 as a potent direct activator of MCs, as well as regulator of their effector phenotype, and have implicated this activity in the ability of mast cells to contribute to murine experimental arthritis. We exp...
متن کاملInterleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice1
BACKGROUND The regulation and function of IgE in healthy individuals and in antigen-naïve animals is not well understood. IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation. METHODS IL-33 was administered to naïve wild-type (WT), nude and ST2(-/-) ,...
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ژورنال
عنوان ژورنال: Journal of Interferon & Cytokine Research
سال: 2014
ISSN: 1079-9907,1557-7465
DOI: 10.1089/jir.2012.0066